Nitroxides. IX. Synthesis of nitroxide free radical α-amino acids

Synthesis and Utilization of α-Substituted Nitroxides

Synthesis of Unnatural Amino Acids Functionalized with Sterically Shielded Pyrroline Nitroxides

A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that L-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.

Synthesis and characterization of dibutyltin compounds with α-amino acids

This study describes the preparation and description of four new complexes: Bu2Sn(AA)Cl (AA = glycine, DL = valine and L = leucine) and Bu2SnPhen2 (Phen = DL-phenylalanine). They were characterized by elemental analyses for carbon, hydrogen, nitrogen, chlorine and tin by infrared, 119mSn-Mössbauer and 119mSnRMN spectroscopies and by the applications of TG and DSC techniques in a dynamic helium ...

Visible-light photoredox synthesis of unnatural chiral α-amino acids

Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required which leads to high cost. Distinctly, it is attractive to make unnatural chiral α-...

A modular synthesis of dithiocarbamate pendant unnatural α-amino acids.

Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.